Research & Development

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     New drug R&D in Neuroscience for senile dementia,  memory loss and neural pain.
     Modified natural product for neuroscience


    • New Progress in 3D Printing for Medical Models and Parts

      3D printed Heart related papers and news release

      Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels  ( Science Advances  23 Oct 2015: Vol. 1, No. 9, e1500758 DOI: 10.1126/sciadv.1500758)

      Fig. 1  FRESH printed scaffolds with complex internal and external architectures based on 3D imaging data from whole organs.

      (A) A dark-field image of an explanted embryonic chick heart. (B) A 3D image of the 5-day-old embryonic chick heart stained for fibronectin (green), nuclei (blue), and F-actin (red) and imaged with a confocal microscope. (C) A cross section of the 3D CAD model of the embryonic heart with complex internal trabeculation based on the confocal imaging data. (D) A cross section of the 3D printed heart in fluorescent alginate (green) showing recreation of the internal trabecular structure from the CAD model. The heart has been scaled up by a factor of 10 to match the resolution of the printer. (E) A dark-field image of the 3D printed heart with internal structure visible through the translucent heart wall. (F) A 3D rendering of a human brain from MRI data processed for FRESH printing. (G) A zoomed-in view of the 3D brain model showing the complex, external architecture of the white matter folds. (H) A lateral view of the brain 3D printed in alginate showing major anatomical features including the cortex and cerebellum. The brain has been scaled down to ~3 mm in length to reduce printing time and test the resolution limits of the printer. (I) A top down view of the 3D printed brain with black dye dripped on top to help visualize the white matter folds printed in high fidelity. Scale bars, 1 mm (A and B) and 1 cm (D, E, H, and I).




      3D-printed hearts help doctors safely train for delicate cardiac surgeries

      TORONTO — The pediatric surgeons hover over a tiny heart, gently retracting delicate inner structures and attaching a graft with impossibly intricate stitches to repair a congenital defect that would mean certain death within days of birth.

      But this heart isn’t inside the chest cavity of a newborn; it’s a 3D-printed model being used at Sick Kids Hospital in Toronto to train cardiac surgeons from around the world in some of the most complex operations they will ever perform during their careers.




      Saving a newborn with the support of 3D Printing

      The 3D printed HeartPrint® model proved to be so valuable that the clinicians at NewYork-Presbyterian/Morgan Stanley Children’s Hospital are already working with Materialise on additional cases. Dr. Bacha added, “After the success of this surgery, it’s hard to imagine entering an operating room for another complex case without the aid of a 3D printed model. It’s definitely going to be standard of care in the future and we’re happy to be leading the way.”  





      3D bioprinting of tissues and organs

      Sean V Murphy1 & Anthony Atala1Nature Biotechnology, 32, 773–785, (2014), doi:10.1038/nbt.2958

      Paper abstract:

      Additive manufacturing, otherwise known as three-dimensional (3D) printing, is driving major innovations in many areas, such as engineering, manufacturing, art, education and medicine. Recent advances have enabled 3D printing of biocompatible materials, cells and supporting components into complex 3D functional living tissues. 3D bioprinting is being applied to regenerative medicine to address the need for tissues and organs suitable for transplantation. Compared with non-biological printing, 3D bioprinting involves additional complexities, such as the choice of materials, cell types, growth and differentiation factors, and technical challenges related to the sensitivities of living cells and the construction of tissues. Addressing these complexities requires the integration of technologies from the fields of engineering, biomaterials science, cell biology, physics and medicine. 3D bioprinting has already been used for the generation and transplantation of several tissues, including multilayered skin, bone, vascular grafts, tracheal splints, heart tissue and cartilaginous structures. Other applications include developing high-throughput 3D-bioprinted tissue models for research, drug discovery and toxicology.

      Figure 1: A typical process for bioprinting 3D tissues.

      Imaging of the damaged tissue and its environment can be used to guide the design of bioprinted tissues. Biomimicry, tissue self-assembly and mini-tissue building blocks are design approaches used singly and in combination.

      Figure 2: Examples of human-scale bioprinted tissues.

      Skin (unpublished; Wake Forest Institute for Regenerative Medicine) and cartilage73 substitutes developed using inkjet bioprinting systems, capable of fabricating tissues either in vitro or in situ.



      The printed organs coming to a body near you

      From kidneys to hands, 3D printers are churning out made-to-order bones and rudimentary organs.

      Printed organs, such as a proto­type outer ear developed by researchers at Princeton University in New Jersey and Johns Hopkins University in Baltimore, Maryland, will be on the agenda at the Inside 3D Printing conference in New York on 15–17 April. The ear is printed from a range of materials: a hydrogel to form an ear-shaped scaffold, cells that will grow to form cartilage, and silver nanoparticles to form an antenna (M. S. Mannoor et al. Nano Lett. 13, 2634−2639; 2013). The device is just one example of the increasing versatility of 3D printing.


      At the Inside 3D Printing conference this week in New York, researchers from academia and industry are gathering to discuss the growing interest in using three-dimensional (3D) printing to make replacement body parts. Although surgeons are already using 3D-printed metal and plastic implants to replace bones, researchers are looking ahead to printing organs using cells as 'ink'. The structures shown here were all 3D printed at Wake Forest Baptist Medical Center in Winston-Salem, North Carolina, and include a rudimentary proto-kidney (top left), complete with living cells.


      3D print building blocks of liver, on course to 3D print entire organ

      We report on many 3D printing developments in the field of medical science. Many of these stories concern 3D printed models of organs, which doctors can use to successfully gain information about particular human bodies to aid surgery. Yesterday we heard a little more about 3D-printed prosthetic limbs, but rarely do we hear about functioning 3D-printed organs. Today it has emerged that a team of Chinese scientists are one step closer to producing a 3D-printed human liver, after they used a specialised 3D bio-printer to build artificial versions of tiny sections of the liver known as hepatic lobules. There are around a million hepatic lobules in a human liver, and the team believes that it can build upon this important development to eventually 3D print an entire liver. If this could be achieved, the implications would be colossal.



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